Cover Page. The handle holds various files of this Leiden University dissertation
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1 Cover Page The handle holds various files of this Leiden University dissertation Author: Slingerland, Marije Title: Exploring novel formulations and new classes of anticancer drugs in solid tumors Issue Date:
2 * Publications
3 Publications Slingerland M, Guchelaar HJ, Rosing H, Scheulen ME, van Warmerdam LJC, Beijnen JH, et al. Bioequivalence of liposome-entrapped paclitaxel easy-to-use (LEP-ETU) formulation and paclitaxel in polyethoxylated castor oil: a randomized, two-period crossover study in patients with advanced cancer. Clin Ther 2013;35; Slingerland M, Guchelaar HJ, Gelderblom H. Histone deacetylase inhibitors: an overview of the clinical studies in solid tumors. Anticancer Drugs 2014;25: Slingerland M, Cerella C, Guchelaar HJ, Diederich M, Gelderblom H. Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials. Invest New Drugs 2013;31: Slingerland M, Kroep JR, Liefers GJ, Scholten AN, Nortier JW. Pregnancy-associated breast cancer: current opinions on diagnosis and treatment. Ned Tijdschr Geneeskd 2012;156:A5286. Slingerland M, Nortier JW, Veenendaal RA, Kapiteijn E. Severe colitis while responding to ipilimumab in metastatic melanoma. Acta Oncol 2012;51: Slingerland M, Guchelaar HJ, Gelderblom H. Liposomal drug formulations in cancer therapy: 15 years along the road. Drug Discov Today 2012;17: Slingerland M, Gelderblom H. The fate of camptothecin glycoconjugate: report of a clinical hold during a phase II study of BAY (formerly BAY ), in patients with recurrent or metastatic colorectal cancer resistant/refractory to irinotecan. Invest New Drugs 2012;30: de Jonge MJ*, Slingerland M*, Loos WJ, Wiemer EA, Burger H, Mathijssen RH, et al. Early cessation of the clinical development of LiPlaCis, a liposomal cisplatin formulation. Eur J Cancer 2010;46: Slingerland M, Nortier JWR. DeVita, Hellman, and Rosenberg s Cancer. Principles & practice of oncology review. 2e druk. Ned Tijdschr Geneeskd 2010;154:A2843. Slingerland M, Teunissen PW, Alleman MJA, Jonkers GJPM. Hepatitis E, endemisch in het Oosten, sporadisch in het Westen. Tijdschr Infect 2007;2: Slingerland M, Plasmeijer EP. De melanocortine-1 receptor in associatie met huidkanker. Ned Tijdschr Geneeskd Studenten Ed 2002;3:51-4. * Authors contributed equally 164
4 * Curriculum vitae
5 Curriculum vitae Marije Slingerland werd geboren op 26 september 1980 te Leiden. In 1998 behaalde zij haar gymnasiumdiploma aan het Ichthus College te Enschede. In 1999 behaalde zij cum laude het propedeutisch examen van de studie Biomedische Wetenschappen aan de Universiteit Leiden en startte zij met de studie Geneeskunde. Haar propedeutisch examen en haar doctoraalexamen behaalde zij in 2000, respectievelijk 2003, beide cum laude. In augustus 2005 behaalde zij haar artsexamen. Aansluitend startte zij met de opleiding tot internist in het Rijnland ziekenhuis te Leiderdorp om in 2008 haar opleiding voort te zetten in het Leids Universitair Medisch Centrum te Leiden (opleiders dr. F.H.M. Cluitmans, prof. dr. J.A. Romijn, prof. dr. J.H. Bolk, prof. dr. J.W.A. Smit, prof. dr. J.W.R. Nortier). In december 2011 volgde de registratie tot internist-oncoloog. Tijdens haar opleiding begon zij met haar promotieonderzoek onder leiding van prof. dr. A.J. Gelderblom en later ook prof. dr. H.-J. Guchelaar, hetgeen heeft geresulteerd in dit proefschrift. In aansluiting op de registratie was zij aanvankelijk tijdelijk als internist-oncoloog werkzaam in het Rijnland ziekenhuis te Leiderdorp tot juli Sindsdien is zij aangesteld als staflid bij de afdeling Klinische Oncologie in het Leids Universitair Medisch Centrum. Haar aandachtsgebieden zijn hoofdhalstumoren, tumoren van de bovenste tractus digestivus, melanomen en fase I studies. De auteur van dit proefschrift woont samen met Martin Meijer en zij hebben twee zoons, Jens en Timo. 166
6 * Dankwoord
7 Dankwoord Graag wil ik iedereen die direct of indirect heeft bijgedragen aan het tot stand komen van dit proefschrift hartelijk bedanken. 168
Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/33676 holds various files of this Leiden University dissertation. Author: Huis-Tanja, Lieke Henriëtte van Title: Pharmacogenetics of capecitabine and oxaliplatin
Cover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/28692 holds various files of this Leiden University dissertation Author: Slingerland, Marije Title: Exploring novel formulations and new classes of anticancer
Cover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/24307 holds various files of this Leiden University dissertation Author: Broek, Colette van den Title: Optimisation of colorectal cancer treatment Issue
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Cover Page The handle http://hdl.handle.net/1887/74052 holds various files of this Leiden University dissertation. Author: Winder, J.Y. Title: The UHDRS and UHDRS-FAP assessments in Huntington's disease
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Cover Page The handle http://hdl.handle.net/1887/28694 holds various files of this Leiden University dissertation. Author: Penning, Maria Elisabeth (Marlies) Title: On renal pathophysiology in preeclampsia
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Cover Page The handle http://hdl.handle.net/1887/44387 holds various files of this Leiden University dissertation. Author: Staveren, M.C. van Title: DPD screening to prevent toxicity in fluoropyrimidine
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Cover Page The handle http://hdl.handle.net/1887/20183 holds various files of this Leiden University dissertation. Author: Rooden, Stephanie Maria van Title: Clinical patterns in Parkinson s disease Date:
Cover Page. The handle http://hdl.handle.net/1887/33832 holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/33832 holds various files of this Leiden University dissertation Author: Krens, Lisanne Title: Refining EGFR-monoclonal antibody treatment in colorectal
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Cover Page The handle http://hdl.handle.net/1887/19332 holds various files of this Leiden University dissertation. Author: Duinen, Nicolette van Title: Hereditary paragangliomas : clinical studies Issue
DANKWOORD. Dankwoord
DANKWOORD Dankwoord Zoals met zoveel zaken in het leven geldt ook voor wetenschap dat het niet alleen leuker maar ook beter is als je samenwerkt. Tijdens het schrijven van dit proefschrift heb ik het geluk
Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/45043 holds various files of this Leiden University dissertation. Author: Plak, R.D. Title: What works for whom? Differential genetic effects of early literacy
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Cover Page The handle http://hdl.handle.net/1887/19123 holds various files of this Leiden University dissertation. Author: Hoohenkerk, Gerard Joannes Franciscus Title: Surgical correction of atrioventricular
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Cover Page The handle http://hdl.handle.net// holds various files of this Leiden University dissertation. Author: Verbiest, Marjolein Elisabeth Anna Title: The implementation of smoking cessation care
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Cover Page The handle http://hdl.handle.net/1887/39113 holds various files of this Leiden University dissertation. Author: Fortuin, Janna Title: Birds of a feather... Selection and socialization processes
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Cover Page The handle http://hdl.handle.net/1887/39413 holds various files of this Leiden University dissertation Author: Reedeker, Nanda Title: Neuropsychiatric phenomena in Huntington s disease Issue
Cover Page. Author: Aa, Marloes van der Title: Diagnosis and treatment of obese children with insulin resistance Issue Date:
Cover Page The handle http://hdl.handle.net/1887/44921 holds various files of this Leiden University dissertation Author: Aa, Marloes van der Title: Diagnosis and treatment of obese children with insulin
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Cover Page The handle http://hdl.handle.net/1887/22866 holds various files of this Leiden University dissertation. Author: Voorthuis, Alexandra Title: Future parents : childhood experiences, oxytocin and
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Cover Page The handle http://hdl.handle.net/1887/51103 holds various files of this Leiden University dissertation Author: Goemans, A. Title: The development of children in foster care Issue Date: 2017-06-27
Jasper, Thomas, Koen, mijn mannetjes, jullie maken de wereld zo mooi.
Nawoord Chapter 11 180 Nawoord Dit proefschrift is het resultaat van de inspanning en hulp van vele mensen. Als eerste wil ik de patiënten bedanken die meegedaan hebben aan deze studies. Zonder hun hulp
Cover Page. Author: Heijden, Thomas van der Title: The interplay between lipids and the immune system in atherosclerosis Date:
Cover Page The handle http://hdl.handle.net/1887/58107 holds various files of this Leiden University dissertation Author: Heijden, Thomas van der Title: The interplay between lipids and the immune system
List of publi cations
13 List of publi cations Publications 215 1. Hoftijzer HC, Kapiteijn E, Schneider T, Hovens GC, Morreau H, Gelderblom H, Smit JW. Tyrosine kinase inhibitors in differentiated thyroid carcinoma: review
University of Groningen. Positron emission tomography in urologic oncology Jong, Igle Jan de
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Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/25308 holds various files of this Leiden University dissertation. Author: Boetzelaer-van Hulsteijn, Leonie Theresia van Title: Paragangliomas Pictured Issue
Publications PUBLICATIONS
Publications 164 Publications PUBLICATIONS 1. Heemskerk B, Veltrop-Duits LA, van Vreeswijk T, ten Dam MM, Heidt S, Toes RE, van Tol MJ, Schilham MW. Extensive cross-reactivity of CD4 + adenovirus-specific
Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/21869 holds various files of this Leiden University dissertation. Author: Schouten, Klaas Jan Pieter Title: Electrocatalytic carbon dioxide reduction :
Cover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/29079 holds various files of this Leiden University dissertation Author: Snijders, Heleen Simone Title: Towards patient-centered colorectal cancer surgery
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Cover Page The handle http://hdl.handle.net/1887/20154 holds various files of this Leiden University dissertation. Author: Joosen, Katharina Jacomina Title: Harsh discipline in toddlerhood. A longitudinal
Dankwoord. Curriculum Vitae
Dankwoord Curriculum Vitae Dankwoord & CV 153 Dankwoord Natuurlijk was dit proefschrift er niet gekomen zonder de hulp en steun van vele mensen. Ik wil iedereen die mij geholpen heeft dan ook bedanken
Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/36476 holds various files of this Leiden University dissertation. Author: Pol, Liselotte Daphne van der Title: Focus on feelings. Parental emotion socialization
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Cover Page The handle http://hdl.handle.net/1887/36475 holds various files of this Leiden University dissertation. Author: Windhorst, Dina Aafje (Dafna) Title: Differential susceptibility to parenting
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Cover Page The handle http://hdl.handle.net/1887/20973 holds various files of this Leiden University dissertation. Author: Hooijkaas, Anna Irene Title: Preclinical optimization of melanoma treatment Issue
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Cover Page The handle http://hdl.handle.net/1887/43530 holds various files of this Leiden University dissertation. Author: Stijntjes, M. Title: Interactions of cognitive and physical ageing Issue Date:
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Cover Page The handle http://hdl.handle.net/1887/37815 holds various files of this Leiden University dissertation. Author: Kleibeuker, Sietske Willemijn Title: 'What Box?': behavioral, neuro-imaging, and
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Cover Page The handle http://hdl.handle.net/1887/37530 holds various files of this Leiden University dissertation. Author: Nielen, Thijs Martinus Johannes Title: Aliteracy : causes and solutions Issue
Risk prediction and risk reduction in patients with manifest arterial disease
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Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/29081 holds various files of this Leiden University dissertation. Author: Schinkel, Linda Danielle van Title: MR assessment of end-organ damage in the metabolic
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Cover Page The handle http://hdl.handle.net/1887/28971 holds various files of this Leiden University dissertation Author: Rosalia, Rodney Alexander Title: Particulate based vaccines for cancer immunotherapy
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Cover Page The handle http://hdl.handle.net/1887/20397 holds various files of this Leiden University dissertation. Author: Anninga, Jakob Klaas Title: Clinical and molecular features of high-grade osteosarcoma
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Cover Page The handle http://hdl.handle.net// holds various files of this Leiden University dissertation. Author: Kröner, Eleanore Sophie Jeanine Title: Magnetic resonance imaging of vessel wall morphology
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Cover Page The handle http://hdl.handle.net/1887/23005 holds various files of this Leiden University dissertation Author: Stoutjesdijk, Regina Title: Children with emotional and behavioral disorders in
PUBLICATIONS Langers P, Cremers SCLM, den Hartigh J, Veenendaal RA, ten Hove WR, Ringers J, Lamers CBHW, van Hoek B. Switching monitoring of emulsified cyclosporine from trough level to 2-hour level in
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Cover Page. The handle http://hdl.handle.net/1887/35807 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/35807 holds various files of this Leiden University dissertation. Author: Wit, Djoeke de Title: Dose optimization of oral targeted therapies in oncology
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Cover Page The handle http://hdl.handle.net/1887/20223 holds various files of this Leiden University dissertation. Author: Spijker, Anne Titia Title: Cortisol exposure, cognition and clinical course of
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Cover Page The handle http://hdl.handle.net/1887/43954 holds various files of this Leiden University dissertation. Author: Soenen, S.M.T.A. Title: Mild intellectual disability : an entity? Mapping clinical
Cover Page. The handle http://hdl.handle.net/1887/37023 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/37023 holds various files of this Leiden University dissertation. Author: Wong, Chung Sing Title: The synthesis of mannose-derived bioconjugates and enzyme
Citation for published version (APA): Crane, L. M. A. (2011). Intraoperative fluorescence imaging in cancer Groningen: s.n.
University of Groningen Intraoperative fluorescence imaging in cancer Crane, Lucia Marie Albertine IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/25012 holds various files of this Leiden University dissertation. Author: Willems, Jorien M. Title: The triad of renal function, erythropoietin and haemoglobin
Cover Page. The handle http://hdl.handle.net/1887/33187 holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/33187 holds various files of this Leiden University dissertation Author: Hidding, Elske Title: Neurocognitive mechanisms and vulnerability to autism and
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Cover Page The handle http://hdl.handle.net/1887/35813 holds various files of this Leiden University dissertation. Author: Hallers-Haalboom, Elizabeth Theodora Title: Mothers and fathers : parenting practices
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DANKWOORD Dit proefschrift is het resultaat van een proces waar velen bij betrokken zijn geweest. Tot een aantal mensen wil ik in het bijzonder het woord richten. Allereerst wil ik alle ouders bedanken
Cover Page. Author: Dikken, Johannes Leen Title: Gastric cancer : staging, treatment, and surgical quality assurance Issue Date: 2012-09-26
Cover Page The handle http://hdl.handle.net/1887/19858 holds various files of this Leiden University dissertation. Author: Dikken, Johannes Leen Title: Gastric cancer : staging, treatment, and surgical
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Cover Page The handle http://hdl.handle.net/1887/18701 holds various files of this Leiden University dissertation. Author: Gent, Tiejo van Title: Mental health problems in deaf and severely hard of hearing
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Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/49612 holds various files of this Leiden University dissertation. Author: Teunissen, Petra Title: Voor 't gewone leven ongeschikt. Een biografie van Clare
Cover Page. The handle http://hdl.handle.net/1887/35006 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/35006 holds various files of this Leiden University dissertation. Author: Pasma, Jantsje Henrieke Title: Impaired standing balance : unraveling the underlying
Cover Page. Author: Emanuel, Marc David Title: The effect of thermal fluctuations on elastic instabilities of biopolymers Issue Date:
Cover Page The handle http://hdl.handle.net/1887/19173 holds various files of this Leiden University dissertation. Author: Emanuel, Marc David Title: The effect of thermal fluctuations on elastic instabilities
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Cover Page The handle http://hdl.handle.net/1887/72513 holds various files of this Leiden University dissertation. Author: Geerse, D.J. Title: A comprehensive approach to assess walking ability and fall
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Cover Page The handle http://hdl.handle.net/1887/18921 holds various files of this Leiden University dissertation. Author: Heusinkveld, Moniek Title: Studies on local APC and HPV-specific T cells as prelude
Anxiety, fainting and gagging in dentistry: Separate or overlapping constructs? van Houtem, C.M.H.H.
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Cover Page. The handle http://hdl.handle.net/1887/35283 holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/35283 holds various files of this Leiden University dissertation Author: Charehbili, Ayoub Title: Optimising preoperative systemic therapy for breast cancer
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Cover Page The handle http://hdl.handle.net/1887/25833 holds various files of this Leiden University dissertation Author: Palenstijn, Willem Jan Title: Radicals in Arithmetic Issue Date: 2014-05-22 Curriculum
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Cover Page The handle http://hdl.handle.net/1887/21795 holds various files of this Leiden University dissertation. Author: Aken, Jill van Title: Studies on undifferentiated and early rheumatoid arthritis
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Cover Page The handle http://hdl.handle.net/1887/22989 holds various files of this Leiden University dissertation Author: Pouw, Lucinda Title: Emotion regulation in children with Autism Spectrum Disorder
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Cover Page The handle http://hdl.handle.net/1887/31463 holds various files of this Leiden University dissertation. Author: Ocak, Gürbey Title: Vascular complications in kidney disease Issue Date: 2015-01-14
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Cover Page The handle http://hdl.handle.net/1887/45778 holds various files of this Leiden University dissertation Author: Korndewal, Marjolein Title: Consequences of congenital cytomegalovirus infection
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Cover Page The handle http://hdl.handle.net/1887/26937 holds various files of this Leiden University dissertation Author: Klein-Wieringa, Inge Ragna Title: Adipose tissue inflammation : implications for
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Cover Page The handle http://hdl.handle.net/1887/29692 holds various files of this Leiden University dissertation Author: Bonten, Tobias N. Title: Time for aspirin : blood pressure and reactivity Issue
Cover Page. The handle http://hdl.handle.net/1887/33832 holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/33832 holds various files of this Leiden University dissertation Author: Krens, Lisanne Title: Refining EGFR-monoclonal antibody treatment in colorectal
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Cover Page The handle http://hdl.handle.net/1887/55514 holds various files of this Leiden University dissertation. Author: Maanen, E.M.T. van Title: Systems pharmacology of the amyloid cascade : unfolding
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Cover Page The handle http://hdl.handle.net/1887/29317 holds various files of this Leiden University dissertation. Author: Nes, Johanna Gerarda Hendrica van Title: Clinical aspects of endocrine therapy
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Cover Page The handle http://hdl.handle.net/1887/45015 holds various files of this Leiden University dissertation Author: Mourits, Esther Title: Een kamer gevuld met de mooiste boeken : de bibliotheek
Cover Page. Author: Meijer, Eline Title: This is [not] who I am : understanding identity in continued smoking and smoking cessation Date:
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Cover Page The handle http://hdl.handle.net/1887/57383 holds various files of this Leiden University dissertation Author: Meijer, Eline Title: This is [not] who I am : understanding identity in continued
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Cover Page The handle http://hdl.handle.net/1887/44325 holds various files of this Leiden University dissertation Author: Rodrigo, Sander F. Title: Intramyocardial bone marrow cell injection for ischemic
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Cover Page The handle http://hdl.handle.net/1887/33063 holds various files of this Leiden University dissertation Author: Tan, Melanie Title: Clinical aspects of recurrent venous thromboembolism Issue
Exploiting natural and induced genetic variation to study hematopoiesis Gerrits, Alice
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Cover Page The handle http://hdl.handle.net/1887/22867 holds various files of this Leiden University dissertation Author: Drewes, Yvonne Title: Strategies in preventive care for older people Issue Date:
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Cover Page The handle http://hdl.handle.net/1887/43352 holds various files of this Leiden University dissertation. Author: Velden, D. van der Title: Mast cell-mediated immune modulation in experimental
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Cover Page The handle http://hdl.handle.net/1887/22212 holds various files of this Leiden University dissertation. Author: Wilde, Adriaan Hugo de Title: Host factors in nidovirus replication Issue Date:
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Cover Page The handle http://hdl.handle.net/1887/31437 holds various files of this Leiden University dissertation Author: Rijssel, Erwin Roelof van Title: Stereoelectronic and conformational effects in
Cover Page. The handle http://hdl.handle.net/1887/18632 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/18632 holds various files of this Leiden University dissertation. Author: Joosse, Simon Andreas Title: Prediction of "BRCAness" in breast cancer by array
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Cover Page The handle http://hdl.handle.net/1887/36026 holds various files of this Leiden University dissertation. Author: Hovens, Jacqueline Gerarda Francisca Maria Title: Emotional scars : impact of
Impact of age, tumor characteristics, an d treatmen t on local con trol an d disease outcome in early stage breast can cer.
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Cover Page The handle http://hdl.handle.net/1887/31604 holds various files of this Leiden University dissertation Author: Kolfschoten, N.E. Title: Measuring quality of care for colorectal cancer care :
List of publications
List of publications 122 List of publications Hoogendam J, Parlevliet ET, Miclea R, Lowik CW, Wit JM, Karperien M. Novel early target genes of parathyroid hormone-related peptide in chondrocytes. Endocrinology
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